Tolerogenic dendritic cells suppress titanium particle-induced inflammation

xlomafota13 shared this article with you from Inoreader Tolerogenic dendritic cells suppress titanium particle-induced inflammation Via Experimental and therapeutic medicine Exp Ther Med. 2021 Jul;22(1):712. doi: 10.3892/etm.2021.10144. Epub 2021 May 3. ABSTRACT Aseptic loosening is a major complication of prosthetic joint surgery. The leading cause of arthroplasty failure is particulate wear debris such as titanium particles. Dendritic cells (DCs) are one type of immune cells that play an important role in the initiation and progression of inflammatory processes. DCs can develop into tolerogenic DCs (tolDCs), which present an alternative therapeutic strategy for inflammatory disorders. Previously, antigen-specific tolDCs were generated, which showed a promising effect in treating inflammatory arthritis and immune thrombocytopenia. The present study reports that tolDCs effectively inhibited titanium particle-induced inflammation in an air-pouch mouse model by decreasing pro-inflammatory cytokines. In addition, a mechanistic study demonstrated that tolDCs significantly protected against titanium particle-in duced inflammatory processes in vitro by releasing anti-inflammatory cytokines, such as interleukin-10. Collectively, these findings not only demonstrate that tolDCs play an important role in inhibiting titanium particle-induced inflammation but also provide a potential alternative for the prevention or treatment of titanium particle-induced inflammation. PMID:34007321 | PMC:PMC8120651 | DOI:10.3892/etm.2021.10144 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.