Update on recurrent mutations in angioimmunoblastic T-cell lymphoma

xlomafota13 shared this article with you from Inoreader Update on recurrent mutations in angioimmunoblastic T-cell lymphoma Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Dec 15;14(12):1108-1118. eCollection 2021. ABSTRACT Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T cell lymphoma (PTCL), defined by genetic alterations that induce abnormal immune activity and inflammatory disorders. Through recent discoveries using genomic studies, the identification of various recurrent mutations has provided greater insight and changed our understanding of the molecular genetics of the disease. By acknowledging these recurrent mutations and their affected pathways, the diagnosis, prognosis, treatment, and survival of AITL can be improved. In this review, we summarize the known recurrent mutations present in the molecular pathogenesis of AITL by emphasizing the effects of mutations on signaling pathways and genes, as well as the multistep process of AITL development. PMID:35027991 | PMC:PMC8748014 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.