Abstract
Objective
The presence of periodontal disease (PD) at a single time point has been suggested as a predictor of diabetes risk, but whether changes in PD status are associated with altered risk of diabetes has yet to be reported on a population scale. This study investigated whether recovery from or development of PD in a population is associated with an altered risk for diabetes occurrence.
Methods
Data of subjects who received health screening from 2002 to 2007 were obtained from the National Health Insurance Service - National Health Screening cohort database of Korea. Patients with a history of diabetes were excluded. Changes in PD status were determined from the first two health screenings. Study subjects were divided into 4 groups according to the changes of PD status: PD-free, PD-recovered, PD-developed, and PD-chronic. The outcome was the occurrence of diabetes.
Results
Overall, 111,611 subjects were included for analysis. During a median follow-up of 9.10 years, diabetes developed in 6,102 subjects. The adjusted hazard ratios (HR) for incident diabetes across various PD change groups (in reference to the PD-free group) were: PD-chronic group=1.096 (95% CI 1.026-1.170, P 0.006); PD-developed group=1.073 (95% CI 0.993-1.159, P 0.075); PD-recovered group=1.019 (CI 0.945-1.100, P 0.622). The subjects who recovered from PD had a lower diabetes risk than those who had consistent PD (adjusted HR 0.930, 95% CI 0.865-1.000, P 0.050), whereas those who developed PD had a higher risk for diabetes than those who remained PD-free.
Conclusion
Longitudinal change in PD status is associated with incident diabetes risk. Future intervention studies are necessary to determine if PD treatment can prevent incident diabetes.
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