NRG Oncology/RTOG 1014: 3 Year Efficacy Report From a Phase II Study of Repeat Breast Preserving Surgery and 3D Conformal Partial Breast Re-Irradiation (PBrI) for In-Breast Recurrence

Publication date: 1 December 2016
Source:International Journal of Radiation Oncology*Biology*Physics, Volume 96, Issue 5
Author(s): D.W. Arthur, J. Moughan, H.M. Kuerer, B.G. Haffty, L.W. Cuttino, D.A. Todor, N.L. Simone, S.B. Hayes, W.A. Woodward, B. McCormick, R.J. Cohen, W.M. Sahijdak, D.J. Canaday, D.R. Brown, A.D. Currey, C.M. Fisher, R. Jagsi, J.R. White




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The KRAS-variant is a Biomarker of Cetuximab Response and Altered Immunity in Head and Neck Cancer: NRG Oncology/RTOG 0522

Publication date: 1 December 2016
Source:International Journal of Radiation Oncology*Biology*Physics, Volume 96, Issue 5
Author(s): J.B. Weidhaas, J. Harris, D. Schaue, A.M. Chen, R.K. Chin, R. Axelrod, A.K. El-Naggar, A.K. Singh, T.J. Galloway, D. Raben, D. Wang, C.L. Matthiesen, V. Avizonis, R. Manon, O. Yumen, P.F. Nguyen-Tan, A. Trotti, H.D. Skinner, Q. Zhang, J. Sayre, R.L. Ferris, D. Sidransky, C. Chung




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Shaping the Immune Landscape in Irradiated Breast Cancer Patients with Systemic TGF-β Blockade

Publication date: 1 December 2016
Source:International Journal of Radiation Oncology*Biology*Physics, Volume 96, Issue 5
Author(s): D. Schaue, M. Xie, J. Ratikan, E. Micewicz, L. Hwang, K. Faull, J. Sayre, P. Lee, J. Glaspy, S. Demaria, S. Formenti, W.H. McBride




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Predictive Factor Analysis of Response-Adapted Radiation Therapy for Chemotherapy-Sensitive Pediatric Hodgkin Lymphoma: Analysis of the Children's Oncology Group AHOD 0031 Trial

Publication date: 1 December 2016
Source:International Journal of Radiation Oncology*Biology*Physics, Volume 96, Issue 5
Author(s): Anne-Marie Charpentier, Debra L. Friedman, Suzanne Wolden, Cindy Schwartz, Bethany Gill, Jenna Sykes, Alisha Albert-Green, Kara M. Kelly, Louis S. Constine, David C. Hodgson
PurposeTo evaluate whether clinical risk factors could further distinguish children with intermediate-risk Hodgkin lymphoma (HL) with rapid early and complete anatomic response (RER/CR) who benefit significantly from involved-field RT (IFRT) from those who do not, and thereby aid refinement of treatment selection.Methods and MaterialsChildren with intermediate-risk HL treated on the Children's Oncology Group AHOD 0031 trial who achieved RER/CR with 4 cycles of chemotherapy, and who were randomized to 21-Gy IFRT or no additional therapy (n=716) were the subject of this study. Recursive partitioning analysis was used to identify factors associated with clinically and statistically significant improvement in event-free survival (EFS) after randomization to IFRT. Bootstrap sampling was used to evaluate the robustness of the findings.ResultAlthough most RER/CR patients did not benefit significantly from IFRT, those with a combination of anemia and bulky limited-stage disease (n=190) had significantly better 4-year EFS with the addition of IFRT (89.3% vs 77.9% without IFRT; P=.019); this benefit was consistently reproduced in bootstrap analyses and after adjusting for other prognostic factors.ConclusionAlthough most patients achieving RER/CR had favorable outcomes with 4 cycles of chemotherapy alone, those children with initial bulky stage I/II disease and anemia had significantly better EFS with the addition of IFRT as part of combined-modality therapy. Further work evaluating the interaction of clinical and biologic factors and imaging response is needed to further optimize and refine treatment selection.



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Efficacy of three-dimensional conformal radiotherapy combined with transarterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus

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Postoperative adjuvant chemotherapy combined with intracavitary brachytherapy in early-stage cervical cancer patients with intermediate risk factors

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History and progression of Fat cadherins in health and disease

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