For avid glucose tumors, the SUV peak is the most reliable parameter for [ 18 F]FDG-PET/CT quantification, regardless of acquisition time

Abstract

Background

This study is an assessment of the impact of acquisition times on SUV with [¹⁸F]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors.

Methods

One hundred six [¹⁸F]FDG-PET/CT were acquired in list mode over a single-bed position (livers (n = 48) or on tumors (n = 58)). Six independent datasets of different durations were reconstructed (from 1.5 to 10 min). SUV_max (hottest voxel), SUV_peak (maximum average SUV within a 1-cm³ spherical volume), and SUV_average were measured within a 3-cm-diameter volume of interest (VOI) in the right lobe of the liver. For [¹⁸F]FDG avid tumors (SUV_max ≥ 5), the SUV_max, SUV_peak, and SUV_41% (isocontour threshold method) were computed.

Results

For tumors, SUV_peak values did not vary with acquisition time. SUV_max displayed significant differences between 1.5- and 5–10-min reconstruction times. SUV_41% was the most time-dependent parameter. For the liver, the SUV_average was the sole parameter that did not vary over time.

Conclusions

For [¹⁸F]FDG avid tumors, with short acquisition times, i.e., with new generations of PET systems, the SUV_peak may be more robust than the SUV_max. The SUV_average over a 3-cm-diameter VOI in the right lobe of the liver appears to be a good method for a robust and reproducible assessment of the hepatic metabolism.

from Cancer via ola Kala on Inoreader http://ift.tt/1QZEClt
via IFTTT