Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests one third of mutations are somatic

We performed targeted sequencing of BRCA1/2 in an unselected cohort of patients diagnosed with primary breast cancer within a population without strong founder mutations. 11% of cases harbored a germline or somatic BRCA1/2 mutation, and the ratio of germline versus somatic mutation was 2:1. This has implications for treatment, genetic counseling, and interpretation of tumor-only testing.

from Cancer via ola Kala on Inoreader http://ift.tt/208I7we
via IFTTT