Timing of breast cancer surgery, menstrual phase, and prognosis: Systematic review and meta-analysis

Publication date: June 2016
Source:Critical Reviews in Oncology/Hematology, Volume 102
Author(s): Hillary Klonoff-Cohen, Ruopeng An, Theodora Fries, Jennifer Le, Georg E. Matt
BackgroundFor over 25 years, there has been a debate revolving around the timing of breast cancer surgery, menstrual cycle, and prognosis.MethodsThis systematic review synthesizes and evaluates the body of evidence in an effort to inform evidence-based practice. A keyword and reference search was performed in PubMed and Web of Science to identify human studies that met the inclusion criteria. A total of 58 studies (48 international and 10 U.S.-based) were identified. We provided a narrative summary on study findings and conducted a meta-analysis on a subset of studies where quantitative information was available.ResultsFindings from both qualitative and quantitative analyses were inconclusive regarding performing breast cancer surgery around a specific phase of the menstrual cycle.ConclusionBased on the Institute of Medicine criteria, evidence is insufficient to recommend a change in current primary breast cancer surgery practice based on menstrual phase.



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