An importance of IL-34 in cancer chemoresistance

The ability of tumor cells to escape immune destruction and their acquired resistance to chemotherapy are major obstacles to effective cancer therapy. Although immune checkpoint therapies such as anti-PD1 address these issues in part, clinical responses remain limited to a subpopulation of patients. In this report, we identified interleukin-34 (IL-34) produced by cancer cells as a driver of chemoresistance. In particular, we found that IL-34 modulated the functions of tumor-associated macrophages to enhance local immunosuppression and to promote the survival of chemoresistant cancer cells by activating AKT signaling. Targeting IL-34 in chemoresistant tumors resulted in a remarkable inhibition of tumor growth when accompanied with chemotherapy. Our results define a pathogenic role for IL-34 in mediating immunosuppression and chemoresistance and identify it as a tractable target for anticancer therapy.

from Cancer via ola Kala on Inoreader http://ift.tt/2bL8gQC
via IFTTT