An Unexpected Chink in the Transcriptional Armor of Plasmacytoid Dendritic Neoplasms

Publication date: 14 November 2016
Source:Cancer Cell, Volume 30, Issue 5
Author(s): Maria Kleppe, Ross L. Levine
In this issue of Cancer Cell, Ceribelli et al. use functional genomic and chemical screening to reveal the existence of a TCF4/BRD4-dependent oncogenic regulatory network in blastic plasmacytoid dendritic cell neoplasm (BPDCN) and demonstrate that BPDCN cells are highly sensitive to therapeutic targeting of this novel dependency.

Teaser

In this issue of Cancer Cell, Ceribelli et al. use functional genomic and chemical screening to reveal the existence of a TCF4/BRD4-dependent oncogenic regulatory network in blastic plasmacytoid dendritic cell neoplasm (BPDCN) and demonstrate that BPDCN cells are highly sensitive to therapeutic targeting of this novel dependency.


from Cancer via ola Kala on Inoreader http://ift.tt/2eBQcMZ
via IFTTT