Κυριακή 4 Δεκεμβρίου 2016

Shedding Light on Fat Dependence in AML [News in Brief]

Scientists have begun unraveling the molecular intricacies that drive the appetite of acute myeloid leukemia for fat. They found that these tumor cells have particularly low levels of PHD3, an enzyme that normally activates ACC2 to repress fatty-acid oxidation. This fuels the cells' metabolic reliance on fat-burning, but also renders them highly susceptible to inhibitors of fatty-acid oxidation.



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