Κυριακή 4 Δεκεμβρίου 2016

Targeting Immune Suppression in Cancer [News in Brief]

Researchers have figured out a way to switch the immunosuppressive phenotype of tumor-associated macrophages to one that's immunostimulatory. By inhibiting PI3K in these macrophages, they significantly suppressed tumor growth in mice; when anti–PD-1 therapy was added to PI3K inhibition, complete and sustained tumor eradication was observed in many cases.



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