Salvage radiation therapy after prostatectomy: Understanding the dose–response effect

We read with interest the paper recently published by King [1]: "The dose–response of salvage radiotherapy following radical prostatectomy: a systematic review and meta-analysis". The authors claimed the existence of a previously suggested dose–effect for salvage radiotherapy [2–4]; they tried to quantify it by fitting 3–6year biochemical relapse free survival (BRFs) data referred to about 10,000 patients from 71 publications. Despite the clear merit of the work, the predictive power of the simple sigmoid model suggested by King was poor, as shown by the large data spread in Fig.

http://ift.tt/2qZAwZ2