Second malignancies after permanent implant prostate cancer brachytherapy: A single-institution study of 675 patients treated between 1999 and 2003

Publication date: Available online 9 May 2017
Source:Cancer/Radiothérapie
Author(s): J.-M. Cosset, L. Belin, G. Wakil, T. Flam, N. Thiounn, N. Pierrat, D. Pontvert, A. Savignoni, L. Chauveinc
PurposeTo analyse the rate of secondary malignancies observed in a series of 675 prostate cancer patients who underwent a permanent implant brachytherapy between 1999 and 2003, and to compare the incidence with the expected rate in a matched general French population.Material and methodsThe cohort included low-risk patients and a selection of "favourable-intermediate" risk patients. All patients were homogeneously treated using an intraoperative dynamic planning prostate brachytherapy technique, with loose 125-iodine seeds and a prescription dose of 145Gy. The mean follow-up was 132 months.ResultsThe 10-year overall survival for the entire cohort was 92% (95% confidence interval [CI]: 90–94). The 10-year relapse-free survival rate was 82% (95% CI: 79–85). Overall, 61 second cancers were registered. When comparing with a matched general French population, the standard incidence ratio (SIR) for bladder cancer was 1.02 (95% CI: 0.46–1.93). For colorectal cancer, the SIR was 0.45 (95% CI: 0.19–0.89). For lung cancer, the SIR was 0.38 (95% CI: 0.17–0.76). The SIR for all cancers was 0.61 (95% CI: 0.47–0.79). When excluding secondary colorectal and lung cancers (both with low SIRs in this series), the SIR for all cancers was 1.06 (95% CI: 0.77–1.29).ConclusionWith a mean follow-up of more than 11 years, this series does not detect any excess risk of second cancers associated with permanent implant prostate brachytherapy. However, due to power limitation, a small increase in the risk of secondary malignancies cannot be totally ruled out.



http://ift.tt/2q6xmQs