Treatment-related non-contiguous radiologic changes in children with diffuse intrinsic pontine glioma treated with expanded irradiation fields and antiangiogenic therapy

Publication date: Available online 24 August 2017
Source:International Journal of Radiation Oncology*Biology*Physics
Author(s): Zoltan Patay, Thomas E. Merchant, Rosa Nguyen, Christopher R. Pierson, Arzu Onar-Thomas, Alberto Broniscer
Among 23 children with diffuse intrinsic pontine glioma who were treated with small-molecule inhibitors and expanded-field local RT, we observed a high incidence of non-contiguous treatment-related abnormalities (NCTRAs) in the brain. On the basis of their imaging features and patterns, we speculate that NCTRA development was secondary to synergistic steno-occlusive vascular effects induced by the combination of expanded clinical target volume RT, potent antiangiogenic therapy, young age, and in one case, possibly a genetic predisposition.



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