Brain Metastases in Lung Cancer With Targetable Mutations—Reply

In Reply We thank Drs Guttman and Berman for their thoughtful comments regarding our article. They raise a question regarding whether treatment should be considered in prognostic indices and specifically whether targeted therapies should be considered in prognostic indices for patients with brain metastases. They also assert that simply receiving tyrosine kinase inhibitor (TKI) therapy is a known predictive biomarker of response for disease within the brain.

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