Τρίτη 12 Δεκεμβρίου 2017

AML Therapy: Wake Up the Guardian and Cut Loose the Executioners

Publication date: 11 December 2017
Source:Cancer Cell, Volume 32, Issue 6
Author(s): Dario C. Altieri
In this issue of Cancer Cell, Pan et al. show that a combination therapy designed to reactivate the p53 tumor suppressor while antagonizing the anti-apoptotic function of Bcl-2 is highly active in preclinical models of refractory acute myeloid leukemia (AML). The results may move the needle in this hard-to-treat malignancy.

Teaser

In this issue of Cancer Cell, Pan et al. show that a combination therapy designed to reactivate the p53 tumor suppressor while antagonizing the anti-apoptotic function of Bcl-2 is highly active in preclinical models of refractory acute myeloid leukemia (AML). The results may move the needle in this hard-to-treat malignancy.


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