Glut3 Addiction: A Druggable Vulnerability in Glioblastoma

Publication date: 11 December 2017
Source:Cancer Cell, Volume 32, Issue 6
Author(s): Severa Bunda, Gelareh Zadeh, Kenneth D. Aldape
The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggable vulnerability in a subpopulation of GBM.

Teaser

The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggable vulnerability in a subpopulation of GBM.


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