Accelerated repopulation (AR) can compromise tumor control after conventional radiotherapy for fast-growing tumors. Standard AR models assume it begins at a fixed time, with repopulation rates independent of the number of clonogens killed. We investigate the validity and significance of an alternative model where onset-time and rate of AR depend on the number of clonogens killed, and thus on dose and dose-fractionation.
http://ift.tt/2IkiZRd
Σάββατο 10 Μαρτίου 2018
Dose dependence of accelerated repopulation in head and neck cancer: Supporting evidence and clinical implications
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