Role of miR-193a in cancer: complexity and factors control the pattern of its expression.

Role of miR-193a in cancer: complexity and factors control the pattern of its expression.

Curr Cancer Drug Targets. 2018 Mar 07;:

Authors: Mamoori A, Gopalan V, Lam AK

Abstract
BACKGROUND: There is emerging data suggest that the non-coding RNA (microRNA 193a or miR-193a) plays key roles in different types of cancers.
OBJECTIVE: This review aims to investigate the functional significance of miR-193a in different cancers according to the information of literature.
METHOD: All the literature concerning miR-193a in cancer in PubMed are analysed.
RESULTS: Several studies proved the association of miR-193a expression patterns with cancer's stages, grades, response to the chemotherapy and even patient survival. Also, miR-193a can be used to differentiate some types of cancer. In cancer, miR-193a can act as a tumour suppressor gene or as an oncogene. Till now, several genetic factors (MAX, RXR α, XB130, P63, P73, AEG-1, HIFs, EGFR, Drosha, DGCR8, Dicer) and epigenetic factors (DNA methylation and long non-coding RNAs) were predicted to control miR-193a expression. They have fundamental effects on its biological behaviour in different types of cancers.
CONCLUSION: miR-193a has significant roles in cancer and can be targeted in the future for cancer therapy by better understanding to the factors that control it's biological behaviour.

PMID: 29521232 [PubMed - as supplied by publisher]

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