Lymph node metastases are among the best predictors of recurrence and of cancer-related death in early-stage colorectal cancers. Yet, despite their clinical and biological relevance, it remains elusive how lymph node metastases develop and whether metastatic seeding is a major bottleneck that restrains genetic heterogeneity of metastatic disease. Clin Cancer Res; 24(9); 2032–4. ©2018 AACR.
See related article by Ulintz et al., p. 2214
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