Combination Therapy with Glucan and Coenzyme Q10 in Murine Experimental Autoimmune Disease and Cancer

Background/Aim: Coenzyme Q₁₀ is a well-accepted anti-oxidant agent known to play a protective role in various physiological and disease processes. Recently, Coenzyme Q₁₀ is gaining attention as a substance with significant anti-inflammatory properties. β-Glucan is the most studied immunomodulator with significant synergetic effects with numerous bioactive molecules. We aimed to evaluate the possible synergistic effects of simultaneous use of coenzyme Q₁₀ with the well-established immune modulator, β-glucan, on immune reactions and cancer development. Materials and Methods: Coenzyme Q₁₀ and β-glucan were used, both in vivo and in vitro, and their effects were evaluated using phagocytosis and cytokine secretion. Results: Our study confirmed the strong anti-inflammatory effects of coenzyme Q₁₀ and showed that these effects were further potentiated with the addition of β-glucan. The anticancer effects of coenzyme Q₁₀ were less pronounced, but stronger, with the addition of β-glucan. Conclusion: There is significant synergy between coenzyme Q₁₀ and β-glucan.

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