[Comment] Poorly specified fasting conditions in clinical research could lead to treatment failure

Oral targeted therapies are an increasingly important group of drugs in modern oncology. With the shift from intravenously to orally administered drugs, absorption has become a novel and prominent cause for variability in systemic exposure. For some orally administered targeted drugs, concomitant ingestion with food significantly increases drug bioavailability.1 Because most oncolytic drugs have a narrow therapeutic range, the method by which patients take their medication might have a strong effect on clinical outcome.

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