Can telomerase activity be unleashed to refine prognosis within ependymoma subgroups?

Ependymoma is the third most common brain tumor in children, which can arise anywhere along the neuroaxis. Although historically considered one entity since the 1920s, recent studies have confirmed that supratentorial and posterior fossa ependymoma are completely different entities, particularly with respect to their cell of origin.^1–3 Despite this, past and current clinical trials still consider ependymoma as one morphologically homogeneous entity.

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