Viral Therapy Gets Personal: A Potential Gene Signature to Predict Susceptibility to Measles Virus Oncolysis

Are oncolytic viruses ready for the clinic in glioblastomas (GBMs)? Perhaps this idea, begun by Dr. R. Martuza (1) more than 25 years ago, is on the verge of clinical application (2). In this issue of the Journal, Kurokawa et al. (3) describe, for the first time, a gene signature in patients that might predict tumor susceptibility to measles virus (MV) infection and, on the basis of this signature, a clinically available drug that turns resistant GBMs into susceptible ones.

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