Biomarker-Driven and Molecularly Targeted Therapies for Pancreatic Adenocarcinoma

Publication date: Available online 5 June 2018

Source: Seminars in Oncology

Author(s): David B. Zhen, Andrew Coveler, Silvia Zanon, Michele Reni, E. Gabriela Chiorean

Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with few effective treatment options. Our knowledge of molecular alterations in PDAC has significantly grown and helped identify new therapeutic targets. The success of immune checkpoint inhibition in mismatch repair deficient tumors, PARP inhibitors for tumors with DNA repair defects, and targeting hyaluronan (HA) with PEGPH20 in patients with high expressing (HA-high) tumors are examples of promising biomarker-driven therapies. We review the major biological mechanisms in PDAC and discuss current and future directions for molecularly targeted therapies in this disease.

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