Spotlight on Glycolysis: A New Target for Cord Blood Expansion

Publication date: 1 June 2018

Source: Cell Stem Cell, Volume 22, Issue 6

Author(s): Andrea M. Patterson, Louis M. Pelus

Umbilical cord blood (UCB) is a highly valuable but low-quantity source of hematopoietic stem cells (HSCs) for life-saving transplantations. Recently in Nature Medicine, Guo et al. (2018) found that antagonism of a glycolysis-blocking pathway enhances ex vivo expansion of long-term HSCs from human UCB.

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