[Comment] Medulloblastoma in infants: the never-ending challenge

Despite substantial improvements in overall survival, management of infants and young children with medulloblastoma remains a major challenge. In this age group, which is loosely defined as from birth to 6 years of age depending on protocol eligibility criteria, treatment is different from that for older children, because of the higher risk of radiation-related injury to the developing brain.1 There is a fine line between success (complete remission with reintegration [reinstatement of regular life], neurological integrity, and few or no side-effects) and catastrophic success (complete remission with poor or no reintegration, and neurological, intellectual, and endocrinological deficits), a difference that is not reflected in crude overall survival results.

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