Cancers, Vol. 12, Pages 2108: The HECT E3 ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders Cancers doi: 10.3390/cancers12082108 Authors: Asia Owais Rama K. Mishra Hiroaki Kiyokawa The HECT (Homologous to the E6-AP Carboxyl Terminus)-family protein E6AP (E6-associated protein), encoded by the UBE3A gene, is a multifaceted ubiquitin ligase that controls diverse signaling pathways involved in cancer and neurological disorders. The oncogenic role of E6AP...
Wed Jul 29, 2020 03:00
Cancers, Vol. 12, Pages 2106: The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities Cancers doi: 10.3390/cancers12082106 Authors: Jacopo Boni Carlota Rubio-Perez Nuria López-Bigas Cristina Fillat Susana de la Luna DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of proteins involved...
Wed Jul 29, 2020 03:00
Cancers, Vol. 12, Pages 2109: Personal Medicine and Bone Metastases: Biomarkers, Micro-RNAs and Bone Metastases Cancers doi: 10.3390/cancers12082109 Authors: Steven L. Wood Janet E. Brown Bone metastasis is a major cause of morbidity within solid tumours of the breast, prostate, lung and kidney. Metastasis to the skeleton is associated with a wide range of complications including bone fractures, spinal cord compression, hypercalcaemia and increased bone pain. Improved treatments for...
Wed Jul 29, 2020 03:00
Cancers, Vol. 12, Pages 2107: Role of MSC in the Tumor Microenvironment Cancers doi: 10.3390/cancers12082107 Authors: Ralf Hass The tumor microenvironment represents a dynamically composed matrix in which tissue-associated cancer cells are embedded together with a variety of further cell types to form a more or less separate organ-like structure. Constantly mutual interactions between cells of the tumor microenvironment promote continuous restructuring and growth in the tumor. A distinct...
Wed Jul 29, 2020 03:00
Cancers, Vol. 12, Pages 2102: Episodic Breathlessness with and without Background Dyspnea in Advanced Cancer Patients Admitted to an Acute Supportive Care Unit Cancers doi: 10.3390/cancers12082102 Authors: Sebastiano Mercadante Claudio Adile Patrizia Ferrera Giuseppe Bonanno Vincenzo Restivo Alessandra Casuccio Aim: To characterize episodic breathlessness (EB) in patients with advanced cancer, and to determine factors influencing its clinical appearance. Methods: A consecutive...
Wed Jul 29, 2020 03:00
Cancers, Vol. 12, Pages 2105: From Interconnection between Genes and Microenvironment to Novel Immunotherapeutic Approaches in Upper Gastro-Intestinal Cancers—A Multidisciplinary Perspective Cancers doi: 10.3390/cancers12082105 Authors: Giulia Accordino Sara Lettieri Chandra Bortolotto Silvia Benvenuti Anna Gallotti Elisabetta Gattoni Francesco Agustoni Emma Pozzi Pietro Rinaldi Cristiano Primiceri Patrizia Morbini Andrea Lancia Giulia Maria Stella Despite...
Wed Jul 29, 2020 03:00
Cancers, Vol. 12, Pages 2103: Development of an Individualized Prediction Calculator for the Benefit of Postoperative Radiotherapy in Patients with Surgically Resected De Novo Stage IV Breast Cancer Cancers doi: 10.3390/cancers12082103 Authors: Byoung Hyuck Kim Suzy Kim Young Il Kim Ji Hyun Chang Ki-Tae Hwang Sup Kim Moon-June Cho Jeanny Kwon Purpose: Locoregional treatment has been increasingly adopted for metastatic breast cancer at presentation. This study aims...
Wed Jul 29, 2020 03:00
Cancers, Vol. 12, Pages 2101: Metastasis of Uveal Melanoma with Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage Cancers doi: 10.3390/cancers12082101 Authors: Siranush Vardanyan Anton Brosig Hartmut Merz Mahdy Ranjbar Vinodh Kakkassery Salvatore Grisanti Aysegül Tura The prolonged storage of glucose as glycogen can promote the quiescence of tumor cells, whereas the accumulation of an aberrant form of...
Wed Jul 29, 2020 03:00
Cancers, Vol. 12, Pages 2104: Novel Targeted Therapies for Metastatic Thyroid Cancer—A Comprehensive Review Cancers doi: 10.3390/cancers12082104 Authors: Mohammad Al-Jundi Shilpa Thakur Sriram Gubbi Joanna Klubo-Gwiezdzinska The knowledge on thyroid cancer biology has grown over the past decade. Thus, diagnostic and therapeutic strategies to manage thyroid cancer are rapidly evolving. With new insights into tumor biology and cancer genetics, several novel therapies have been...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1805: PKHhigh/CD133+/CD24− Renal Stem-Like Cells Isolated from Human Nephrospheres Exhibit In Vitro Multipotency Cells doi: 10.3390/cells9081805 Authors: Silvia Bombelli Chiara Meregalli Chiara Grasselli Maddalena M. Bolognesi Antonino Bruno Stefano Eriani Barbara Torsello Sofia De Marco Davide P. Bernasconi Nicola Zucchini Paolo Mazzola Cristina Bianchi Marco Grasso Adriana Albini Giorgio Cattoretti Roberto A. Perego The...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1803: iPS-Derived Early Oligodendrocyte Progenitor Cells from SPMS Patients Reveal Deficient In Vitro Cell Migration Stimulation Cells doi: 10.3390/cells9081803 Authors: Lidia Lopez-Caraballo Jordi Martorell-Marugan Pedro Carmona-Sáez Elena Gonzalez-Munoz The most challenging aspect of secondary progressive multiple sclerosis (SPMS) is the lack of efficient regenerative response for remyelination, which is carried out by the endogenous population of adult...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1804: Nuclear Accumulation of LAP1:TRF2 Complex During DNA Damage Response Uncovers a Novel Role for LAP1 Cells doi: 10.3390/cells9081804 Authors: Cátia D. Pereira Filipa Martins Mariana Santos Thorsten Müeller Odete A. B. da Cruz e Silva Sandra Rebelo Lamina-associated polypeptide 1 (LAP1) is a nuclear envelope (NE) protein whose function remains poorly characterized. In a recent LAP1 protein interactome study, a putative regulatory role in the DNA...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1802: Biological Properties of JNK3 and Its Function in Neurons, Astrocytes, Pancreatic β-Cells and Cardiovascular Cells Cells doi: 10.3390/cells9081802 Authors: Rei Nakano Tomohiro Nakayama Hiroshi Sugiya JNK is a protein kinase, which induces transactivation of c-jun. The three isoforms of JNK, JNK1, JNK2, and JNK3, are encoded by three distinct genes. JNK1 and JNK2 are expressed ubiquitously throughout the body. By contrast, the expression of JNK3 is limited...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1798: Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development Cells doi: 10.3390/cells9081798 Authors: Muhammad Idrees Seon-Hwa Oh Tahir Muhammad Marwa El-Sheikh Seok-Hwan Song Kyeong-Lim Lee Il-Keun Kong Growth factors and cytokines have vital roles in germ cell development, gamete maturation, and early embryo development. Cell surface receptors are present for growth factors...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1800: Transcriptomic Profiling of Ca2+ Transport Systems During the Formation of the Cerebral Cortex in Mice Cells doi: 10.3390/cells9081800 Authors: Alexandre Bouron Cytosolic calcium (Ca2+) transients control key neural processes, including neurogenesis, migration, the polarization and growth of neurons, and the establishment and maintenance of synaptic connections. They are thus involved in the development and formation of the neural system. In this study, a publicly...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1799: MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress Cells doi: 10.3390/cells9081799 Authors: Sardar Sindhu Nadeem Akhter Ajit Wilson Reeby Thomas Hossein Arefanian Ashraf Al Madhoun Fahd Al-Mulla Rasheed Ahmad Metabolic inflammation is associated with increased expression of saturated free fatty acids, proinflammatory cytokines,...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1797: Feasibility of Mechanical Extrusion to Coat Nanoparticles with Extracellular Vesicle Membranes Cells doi: 10.3390/cells9081797 Authors: Jan Van Deun Quentin Roux Sarah Deville Thibaut Van Acker Pekka Rappu Ilkka Miinalainen Jyrki Heino Frank Vanhaecke Bruno G. De Geest Olivier De Wever An Hendrix Biomimetic functionalization to confer stealth and targeting properties to nanoparticles is a field of intense study. Extracellular vesicles...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1801: Wnt-5A/B Signaling in Hematopoiesis throughout Life Cells doi: 10.3390/cells9081801 Authors: Marina Mastelaro de Rezende Giselle Zenker Justo Edgar Julian Paredes-Gamero Reinoud Gosens Wnt signaling is well-known to play major roles in the hematopoietic system, from embryogenesis to aging and disease. In addition to the main β-catenin-dependent pathway, it is now clear that Wnt5a and the structurally related Wnt5b are essential for hematopoiesis,...
Wed Jul 29, 2020 03:00
Cells, Vol. 9, Pages 1796: Comment on: “Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. Cells 2020, 9, 197” Cells doi: 10.3390/cells9081796 Authors: Allen Herbst Judd M. Aiken Debbie McKenzie Jonathan Wanagat “The main conclusions are that the ageing atrophy begins as early as around 25 years of age and thereafter accelerates and, for this muscle, is caused mainly by a loss of fibers and to a lesser extent by a reduction in fiber size [...]
Wed Jul 29, 2020 03:00
Children, Vol. 7, Pages 84: Upper Extremity Fractures in Children—Comparison between Worldwide, Romanian and Western Romanian Region Incidence Children doi: 10.3390/children7080084 Authors: Ovidiu Adam Florin George Horhat Elena Amaricai Vlad-Laurentiu David Zoltán Derzsi Eugen Sorin Boia (1) Background: Fractures represent a significant part of all pediatric injuries, with distal forearm fracture being the most common fracture type in children. (2) Methods: In this comparative,...
Wed Jul 29, 2020 03:00
Climate, Vol. 8, Pages 89: Trend Analysis of air Temperature in the Federal District of Brazil: 1980–2010 Climate doi: 10.3390/cli8080089 Authors: Valdir Adilson Steinke Luis Alberto Martins Palhares de Melo Mamedes Luiz Melo Rafael Rodrigues da Franca Rebecca Luna Lucena Ercilia Torres Steinke This study was designed to identify trends in maximum, minimum, and average air temperatures in the Federal District of Brazil from 1980 to 2010, measured at five weather...
Wed Jul 29, 2020 03:00
Diagnostics, Vol. 10, Pages 530: Incidental Severe Fatty Degeneration of the Erector Spinae in a Patient with L5–S1 Disc Extrusion Diagnosed with Limb-Girdle Muscular Dystrophy R2 Dysferin-related Diagnostics doi: 10.3390/diagnostics10080530 Authors: Du Hwan Kim Dae-Hyun Jang Ja-Hyun Jang Limb-girdle muscular dystrophy type R2 dysferin-related (LGMD R2 dysferin-related), a phenotype of dysferlinopathy, usually begins with pelvic girdle weakness. A 35-year-old male presented with...
Wed Jul 29, 2020 03:00
Diagnostics, Vol. 10, Pages 529: Home-Based Functional Electrical Stimulation of Human Permanent Denervated Muscles: A Narrative Review on Diagnostics, Managements, Results and Byproducts Revisited 2020 Diagnostics doi: 10.3390/diagnostics10080529 Authors: Helmut Kern Ugo Carraro Spinal cord injury (SCI) produces muscle wasting that is especially severe after complete and permanent damage of lower motor neurons, as can occur in complete conus and cauda equina syndrome. Even in this...
Wed Jul 29, 2020 03:00
Diagnostics, Vol. 10, Pages 531: Early Onset Preeclampsia Diagnosis Prior to the 20th Week of Gestation in a Twin Pregnancy Managed via Selective Reduction of an Intrauterine Growth Restriction Fetus: A Case Report and Literature Review Diagnostics doi: 10.3390/diagnostics10080531 Authors: Anastasios Konstantopoulos Konstantinos Sfakianoudis Mara Simopoulou Adamantia Kontogeorgi Anna Rapani Sokratis Grigoriadis Agni Pantou Nikolaos Bathrellos Alexandros Grammatis Konstantinos...
Wed Jul 29, 2020 03:00
Diagnostics, Vol. 10, Pages 527: Non-Small-Cell Lung Cancer-Sensitive Detection of the p.Thr790Met EGFR Alteration by Preamplification before PNA-Mediated PCR Clamping and Pyrosequencing Diagnostics doi: 10.3390/diagnostics10080527 Authors: Amandine Billaud Veronique Verriele Jonathan Dauvé Louise-Marie Chevalier Alain Morel Targeted therapies and, more precisely, EGFR tyrosine kinase inhibitors (TKIs) have been a major improvement in the therapeutic management of EGFR-mutated...
Wed Jul 29, 2020 03:00
Diagnostics, Vol. 10, Pages 528: Characterization of PD-1/PD-L1 Immune Checkpoint Expression in Osteosarcoma Diagnostics doi: 10.3390/diagnostics10080528 Authors: Kazuhiko Hashimoto Shunji Nishimura Masao Akagi Recent data have suggested that PD-1 and PD-L1 are involved in osteosarcoma (OS) pathogenesis; however, their contributions are not well-established. Here, the PD-1/PD-L1 expression was evaluated in (OS) cases. Preoperative needle biopsy specimens were obtained from 16 patients...
Wed Jul 29, 2020 03:00
Diagnostics, Vol. 10, Pages 526: “NO LOAD” Resistance Training Promotes High Levels of Knee Extensor Muscles Activation—A Pilot Study Diagnostics doi: 10.3390/diagnostics10080526 Authors: Rafael Ribeiro Alves Carlos Alexandre Vieira Martim Bottaro Murilo Augusto Soares de Araújo Daniel Costa Souza Bruno Cavalcante Gomes Paulo Gentil The present article aims to compare electromyographic (EMG) activity of the knee extensors during traditional resistance training (TRT)...
Wed Jul 29, 2020 03:00
Diversity, Vol. 12, Pages 298: Cyanobacteria Phylogenetic Studies Reveal Evidence for Polyphyletic Genera from Thermal and Freshwater Habitats Diversity doi: 10.3390/d12080298 Authors: Rita Cordeiro Rúben Luz Vitor Vasconcelos Vítor Gonçalves Amélia Fonseca Cyanobacteria are among the most diverse morphological microorganisms that inhabit a great variety of habitats. Their presence in the Azores, a volcanic archipelago of nine islands in the middle of the North Atlantic Ocean,...
Wed Jul 29, 2020 03:00
Diversity, Vol. 12, Pages 297: Phenotypic Variation in Endangered Texas Salamanders: Application of Model-Based Clustering for Identifying Species and Hybrids Diversity doi: 10.3390/d12080297 Authors: Donella M. Strom Nathan F. Bendik Dee Ann Chamberlain Jessica A. Watson Jesse M. Meik The endangered Barton Springs and Austin blind salamanders (Eurycea sosorum and E. waterlooensis, respectively) are micro-endemics to the Barton Springs segment of the Edwards Aquifer and its...
Wed Jul 29, 2020 03:00
Environments, Vol. 7, Pages 55: Evaluation of the Copper and Zinc Contents of Soils in the Vineyards of La Rioja (Spain) Environments doi: 10.3390/environments7080055 Authors: Victoria Iñigo Alvaro Marín Marisol Andrades Raimundo Jiménez-Ballesta The aim of this study was to determine the concentrations of Cu and Zn in soils in the vineyards of La Rioja and to calculate reference values for the two elements. Samples were taken from the surface horizon (0–20 cm) and...
Wed Jul 29, 2020 03:00
Environments, Vol. 7, Pages 56: Economic Valuation of Green Infrastructure Investments in Urban Renewal: The Case of the Station District in Taichung, Taiwan Environments doi: 10.3390/environments7080056 Authors: Kuo-Wei Hsu Jen-Chih Chao The extreme weather conditions that are increasingly affecting Taiwan require urgent solutions, especially as land-use pressures and intensive urban development are triggering new types of vulnerability to natural disasters. Green infrastructure...
Wed Jul 29, 2020 03:00
Fermentation, Vol. 6, Pages 76: Non-Saccharomyces in Winemaking: Source of Mannoproteins, Nitrogen, Enzymes, and Antimicrobial Compounds Fermentation doi: 10.3390/fermentation6030076 Authors: Ricardo Vejarano Traditionally, non-Saccharomyces yeasts have been considered contaminants because of their high production of metabolites with negative connotations in wine. This aspect has been changing in recent years due to an increased interest in the use of these yeasts in the winemaking process....
Wed Jul 29, 2020 03:00
Fermentation, Vol. 6, Pages 75: Yeast Biotechnology 3.0 Fermentation doi: 10.3390/fermentation6030075 Authors: Ronnie G. Willaert This Special Issue is a continuation of the first and second “Yeast Biotechnology” Special Issue series of the journal Fermentation (MDPI) [...]
Wed Jul 29, 2020 03:00
Foods, Vol. 9, Pages 1018: Extraction and Characterization of Antioxidant Peptides from Fruit Residues Foods doi: 10.3390/foods9081018 Authors: Saúl Olivares-Galván María Luisa Marina María Concepción García Fruit residues with high protein contents are generated during the processing of some fruits. These sustainable sources of proteins are usually discarded and, in all cases, underused. In addition to proteins, these residues can also be sources of peptides with protective effects...
Wed Jul 29, 2020 03:00
Foods, Vol. 9, Pages 1017: Effects of Olive Leaf Extracts as Natural Preservative on Retailed Poultry Meat Quality Foods doi: 10.3390/foods9081017 Authors: Ebeed Saleh Alaa Eldin Morshdy Eman El-Manakhly Sarah Al-Rashed Helal F. Hetta Philippe Jeandet Ramadan Yahia Gaber El-Saber Batiha Eman Ali Poultry meat is commonly marketed at refrigerated temperatures (2–5 °C). The major concern for retailers and consumers is the quality and safety of refrigerated...
Wed Jul 29, 2020 03:00
Foods, Vol. 9, Pages 1016: Green Processing, Germinating and Wet Milling Brown Rice (Oryza sativa) for Beverages: Physicochemical Effects Foods doi: 10.3390/foods9081016 Authors: John C. Beaulieu Shawndrika S. Reed Javier M. Obando-Ulloa Stephen M. Boue Marsha R. Cole Plant-based beverage consumption is increasing markedly. Value-added dehulled rice (Oryza sativa) germination was investigated to improve beverage qualities. Germinating brown rice has been shown to increase...
Wed Jul 29, 2020 03:00
Foods, Vol. 9, Pages 1015: Foraging in Boreal Forest: Wild Food Plants of the Republic of Karelia, NW Russia Foods doi: 10.3390/foods9081015 Authors: Valeria Kolosova Olga Belichenko Alexandra Rodionova Denis Melnikov Renata Sõukand While the current consumption of wild food plants in the taiga of the American continent is a relatively well-researched phenomenon, the European taiga area is heavily underrepresented in the scientific literature. The region is important due...
Wed Jul 29, 2020 03:00
Geriatrics, Vol. 5, Pages 44: Changes in Treatment of Very Elderly Patients Six Weeks after Discharge from Geriatrics Department Geriatrics doi: 10.3390/geriatrics5030044 Authors: Mélanie Dipanda Jérémy Barben Gilles Nuémi Lucie Vadot Valentine Nuss Jérémie Vovelle Alain Putot Patrick Manckoundia We assessed the prescriptions of patients hospitalized in a geriatric unit and subsequently discharged. This prospective and observational study was conducted over a two-month...
Wed Jul 29, 2020 03:00
Healthcare, Vol. 8, Pages 243: Enhancing Privacy and Data Security across Healthcare Applications Using Blockchain and Distributed Ledger Concepts Healthcare doi: 10.3390/healthcare8030243 Authors: Haibing Liu Rubén González Crespo Oscar Sanjuán Martínez Nowadays, blockchain is developing as a secure and trustworthy platform for secure information sharing in areas of application like banking, supply chain management, food industry, energy, the Internet, and medical services. Besides,...
Wed Jul 29, 2020 03:00
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