Related Articles Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy. Molecules. 2020 Jul 23;25(15): Authors: Montané X, Kowalczyk O, Reig-Vano B, Bajek A, Roszkowski K, Tomczyk R, Pawliszak W, Giamberini M, Mocek-Płóciniak A, Tylkowski B Abstract The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial...
Wed Jul 29, 2020 14:28
Related Articles Comparison of Multiplexed Immunofluorescence Imaging to Chromogenic Immunohistochemistry of Skin Biomarkers in Response to Monkeypox Virus Infection. Viruses. 2020 Jul 23;12(8): Authors: Sood A, Sui Y, McDonough E, Santamaría-Pang A, Al-Kofahi Y, Pang Z, Jahrling PB, Kuhn JH, Ginty F Abstract Over the last 15 years, advances in immunofluorescence-imaging based cycling methods, antibody conjugation methods, and automated image...
Wed Jul 29, 2020 14:28
Related Articles COVID-19 and androgen-targeted therapy for prostate cancer patients. Endocr Relat Cancer. 2020 09;27(9):R281-R292 Authors: Bhowmick NA, Oft J, Dorff T, Pal S, Agarwal N, Figlin RA, Posadas EM, Freedland SJ, Gong J Abstract The current pandemic (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health challenge with active development of antiviral drugs and vaccines seeking to reduce...
Wed Jul 29, 2020 14:28
Related Articles Essential Thrombocythemia Presenting with Recurrent Priapism: A Case Report and Review of Literature. Am J Case Rep. 2020 Jul 28;21:e924455 Authors: Verma SP, Kumar N, Jain M, Tripathi AK Abstract BACKGROUND Priapism is rarely reported as a complication in patients with essential thrombocythemia at presentation. We could find very few such cases of essential thrombocythemia while searching the literature. A combined modality...
Wed Jul 29, 2020 14:40
Related Articles Surgical Management of Giant Colonic Diverticulum Presenting After Laparoscopic Lavage for Diverticular Perforation and Sepsis. Am J Case Rep. 2020 Jul 28;21:e923457 Authors: Chino JR, Rayhrer CS, Barrows BD, Salehpour MM Abstract BACKGROUND Diverticulosis and its complication of diverticulitis is a common condition that can be found in up to 35% of the population. Giant colonic diverticulum is a rare entity with fewer than...
Wed Jul 29, 2020 14:40
Related Articles Low Humoral Immune Response and Ineffective Clearance of SARS-Cov-2 in a COVID-19 Patient With CLL During a 69-Day Follow-Up. Front Oncol. 2020;10:1272 Authors: Ye X, Xiao X, Li B, Zhu W, Li Y, Wu J, Huang X, Jin J, Chen D, Jin J, Huang J Abstract Background: A recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), which began in Wuhan, China, with a high level of human-to-human transmission has been...
Wed Jul 29, 2020 14:47
Related Articles Screening Strategies for COVID-19 in Patients With Hematologic Malignancies. Front Oncol. 2020;10:1267 Authors: Assi T, Samra B, Dercle L, Rassy E, Kattan J, Ghosn M, Houot R, Ammari S Abstract COVID-19 has been declared a pandemic by the world health organization. Patients with cancer, and particularly hematologic malignancies may be at higher risk for severe complications due to their malignancy, immune dysregulation, therapy,...
Wed Jul 29, 2020 14:47
Related Articles Nomogram for Predicting the Overall Survival of Adult Patients With Primary Gastrointestinal Diffuse Large B Cell Lymphoma: A SEER- Based Study. Front Oncol. 2020;10:1093 Authors: Wang J, Zhou M, Zhou R, Xu J, Chen B Abstract Background: The aim of this study was to establish a precise prognostic model, based on significant clinical parameters, for predicting the overall survival (OS) of adult patients with primary gastrointestinal...
Wed Jul 29, 2020 14:47
The Role of Transcriptional Factor Brachyury on Cell Cycle Regulation in Non-small Cell Lung Cancer.
Related Articles The Role of Transcriptional Factor Brachyury on Cell Cycle Regulation in Non-small Cell Lung Cancer. Front Oncol. 2020;10:1078 Authors: Xu J, Chen M, Wu Y, Zhang H, Zhou J, Wang D, Zou T, Shen J Abstract Lung cancer is the leading cause of cancer-related death, and non-small cell lung cancer (NSCLC) accounts for almost 80-85% of all lung cancer cases. The transcriptional factor brachyury has been verified to promote tumor cells...
Wed Jul 29, 2020 14:47
Related Articles Proteomic Analysis of the Air-Way Fluid in Lung Cancer. Detection of Periostin in Bronchoalveolar Lavage (BAL). Front Oncol. 2020;10:1072 Authors: Zhou Y, Yang W, Ao M, Höti N, Gabrielson E, Chan DW, Zhang H, Li QK Abstract Background: Bronchoalveolar lavage (BAL) is a specific type of air-way fluid. It is a commonly used clinical specimen for the diagnosis of benign diseases and cancers of the lung. Although previous studies...
Wed Jul 29, 2020 14:47
Related Articles TIPRL, a Novel Tumor Suppressor, Suppresses Cell Migration, and Invasion Through Regulating AMPK/mTOR Signaling Pathway in Gastric Cancer. Front Oncol. 2020;10:1062 Authors: Luan M, Shi SS, Shi DB, Liu HT, Ma RR, Xu XQ, Sun YJ, Gao P Abstract Invasion and metastasis of gastric cancer after curative resection remain the most common lethal outcomes. However, our current understanding of the molecular mechanism underlying gastric...
Wed Jul 29, 2020 14:47
Related Articles Stereotactic Body Radiation Therapy (SBRT) for Prostate Cancer in Men With a High Baseline International Prostate Symptom Score (IPSS ≥ 15). Front Oncol. 2020;10:1060 Authors: Aghdam N, Pepin A, Buchberger D, Hirshberg J, Lei S, Ayoob M, Danner M, Yung T, Kumar D, Collins BT, Lynch J, Kataria S, Suy S, Collins SP Abstract Background: Patients with a high pretreatment IPSS may have higher rates of late urinary morbidity after...
Wed Jul 29, 2020 14:47
Related Articles Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis. Front Oncol. 2020;10:994 Authors: Mancarella C, Caldoni G, Ribolsi I, Parra A, Manara MC, Mercurio AM, Morrione A, Scotlandi K Abstract Ewing sarcoma (EWS) is the second most common bone and soft tissue-associated malignancy in children and young adults. It is driven by the fusion oncogene EWS/FLI1...
Wed Jul 29, 2020 14:47
Related Articles Automated Quality Assurance of OAR Contouring for Lung Cancer Based on Segmentation With Deep Active Learning. Front Oncol. 2020;10:986 Authors: Men K, Geng H, Biswas T, Liao Z, Xiao Y Abstract Purpose: Ensuring high-quality data for clinical trials in radiotherapy requires the generation of contours that comply with protocol definitions. The current workflow includes a manual review of the submitted contours, which is time-consuming...
Wed Jul 29, 2020 14:47
Related Articles Evaluation of the Efficacy and Safety of PARP Inhibitors in Advanced-Stage Epithelial Ovarian Cancer. Front Oncol. 2020;10:954 Authors: Jiang Y, Zhao J, Zhang L, Tian S, Yang T, Wang L, Zhao M, Yang Q, Wang Y, Yang X Abstract Purpose: PARP inhibitors are a novel targeted anti-cancer drug and a large number of clinical studies on PARP inhibitors have been accomplished. This updated meta-analysis was conducted to evaluate the...
Wed Jul 29, 2020 14:47
Related Articles Disseminated Juvenile Xanthogranuloma and Hemophagocytic Lymphohistiocytosis Developed During Treatment of Acute Lymphoblastic Leukemia: Case Report. Front Oncol. 2020;10:921 Authors: Pawińska-Wa Sikowska K, Cwiklinska M, Wyrobek E, Balwierz W, Bukowska-Strakova K, Dluzniewska A, Gozdzik J, Drabik G, Rygielska M, Stepien K, Skoczen S Abstract The association between acute lymphoblastic leukemia (ALL), non-Langerhans cell histiocytosis...
Wed Jul 29, 2020 14:47
Related Articles Real-World Evidence in Glioblastoma: Stupp's Regimen After a Decade. Front Oncol. 2020;10:840 Authors: Lakomy R, Kazda T, Selingerova I, Poprach A, Pospisil P, Belanova R, Fadrus P, Vybihal V, Smrcka M, Jancalek R, Hynkova L, Muckova K, Hendrych M, Sana J, Slaby O, Slampa P Abstract The aim of this retrospective study is to provide real-world evidence in glioblastoma treatment and to compare overall survival after Stupp's regimen...
Wed Jul 29, 2020 14:47
Related Articles The Utility of Platelet-Rich Plasma for the Treatment of Alopecia. J Drugs Dermatol. 2020 Jul 01;19(7):736-741 Authors: Juhasz MLW, Lo Sicco K, Shapiro J Abstract Importance: Platelet-rich plasma (PRP) is a novel therapy for alopecia. Although the use of PRP remains under investigation, medical practitioners administer PRP for hair regrowth without quantitative evidence of clinical results. Objective: Systematically review...
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Related Articles A Review of Vitamin D and Scarring: The Potential for New Therapeutics. J Drugs Dermatol. 2020 Jul 01;19(7):742-745 Authors: Akoh CC, Orlow SJ Abstract Introduction: Recent research on vitamin D has shown that the fat-soluble micronutrient has anti-microbial, anti-inflammatory, and anti-proliferative effects in cells and tissues. During wound healing, abnormal scarring may occur and lead to reduced mobility, disfigurement,...
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Related Articles Ocular Dermoid in Patient With Basal Cell Nevus Syndrome. J Drugs Dermatol. 2020 Jul 01;19(7):792 Authors: Shah M, Hanke W Abstract A 47-year-old women presented for Mohs Micrographic Surgery for a biopsy proven basal cell carcinoma involving the right nasal ala. The patient had a history of basal cell nevus syndrome (BCNS) and previous history of multiple basal cell carcinomas. PMID: 32721139 [PubMed - as supplied...
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Related Articles Descriptive epidemiology of incidence and mortality of primary liver cancer in 185 countries: evidence from GLOBOCAN 2018. Jpn J Clin Oncol. 2020 Jul 28;: Authors: Sharma R Abstract PURPOSE: This study aims to examine the burden of primary liver cancer in 185 countries in 2018. METHODS: The estimates of incidence, mortality and prevalence of primary liver cancer were procured from GLOBOCAN 2018. The development status...
Wed Jul 29, 2020 13:27
Related Articles Rare cancers in Japan: definition, clinical features and future perspectives. Jpn J Clin Oncol. 2020 Jul 28;: Authors: Kawai A, Higashi T, Shibata T, Yoshida A, Katoh Y, Fujiwara Y, Nishida T Abstract This review introduces the definition, epidemiology and therapeutic challenges of rare cancers and describes the establishment of the Rare Cancer Center at the National Cancer Center, Japan. Rare cancers are defined as malignant...
Wed Jul 29, 2020 13:27
Related Articles Stereotactic body radiotherapy for bone metastases in patients with colorectal cancer. Jpn J Clin Oncol. 2020 Jul 28;: Authors: Ito K, Yamaguchi T, Ogawa H, Nakajima Y, Karasawa K Abstract OBJECTIVE: To clarify the clinical outcomes of stereotactic body radiotherapy for colorectal cancer-derived bone metastases and identify factors predicting treatment failure. METHODS: Patients treated with stereotactic body radiotherapy...
Wed Jul 29, 2020 13:27
Related Articles The influence of dynamic changes in lipid metabolism on survival outcomes in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors. Jpn J Clin Oncol. 2020 Jul 28;: Authors: Zhang X, Zhang H, Dai J, Liu Z, Zhu X, Ni Y, Yin X, Sun G, Zhu S, Chen J, Zhao J, Wang J, Zeng H, Shen P Abstract BACKGROUND: The role of lipid metabolic status in tyrosine kinase inhibitors-treated patients with metastatic...
Wed Jul 29, 2020 13:27
Related Articles Telemedicine in Minority and Socioeconomically Disadvantaged Communities Amidst COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 Jul 28;:194599820947667 Authors: Ramirez AV, Ojeaga M, Espinoza V, Hensler B, Honrubia V Abstract In the wake of the COVID-19 pandemic, many otolaryngology practices worldwide have chosen to shift their consultations from in-person to telemedicine. The addition of the telemedicine model has...
Wed Jul 29, 2020 16:50
Related Articles Assessing the Practice Characteristics of Otolaryngology Same-Day Appointments in an Academic Center. Otolaryngol Head Neck Surg. 2020 Jul 28;:194599820942497 Authors: Geelan-Hansen K, Were V, Granger K, Jones D Abstract OBJECTIVES: to Examine the practice characteristics of same-day clinic appointments and the use of same-day appointment scheduling to provide access to care in an otolaryngology-head and neck surgery clinic....
Wed Jul 29, 2020 16:50
Related Articles Hearing Vital Signs: Mobile Audiometry in the Emergency Department for Evaluation of Sudden Hearing Loss. Otolaryngol Head Neck Surg. 2020 Jul 28;:194599820935420 Authors: Lubner RJ, Barbarite E, Kondamuri N, Knoll RM, Ota HG, Lewis RM, Franck K, Remenschneider AK, Kozin ED Abstract Emergency departments (EDs) are a common location for patients to present with sudden hearing loss (SHL). Unfortunately, high-quality, rapid...
Wed Jul 29, 2020 16:50
Related Articles Pre-operative Imaging Characteristics in Histology-Proven Resected Intrahepatic Cholangiocarcinoma. World J Surg. 2020 Jul 27;: Authors: Cheng N, Khoo N, Chung AYF, Goh BKP, Cheow PC, Chow PKH, Lee SY, Ooi LL, Jeyaraj PR, Kam JH, Koh YX, Chan CY, Teo JY Abstract BACKGROUND: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common primary liver cancers. With the increasing incidence of ICC...
Wed Jul 29, 2020 13:11
Related Articles Tumorigenic effects of TLX overexpression in HEK 293T cells. Cancer Rep (Hoboken). 2019 Oct;2(5):e1204 Authors: Parris TZ, Vizlin-Hodzic D, Salmela S, Funa K Abstract BACKGROUND: The human orphan receptor TLX (NR2E1) is a key regulator of neurogenesis, adult stem cell maintenance, and tumorigenesis. However, little is known about the genetic and transcriptomic events that occur following TLX overexpression in human cell...
Wed Jul 29, 2020 13:44
Related Articles Valproic Acid Sensitizes Glioma Cells to Luteolin Through Induction of Apoptosis and Autophagy via Akt Signaling. Cell Mol Neurobiol. 2020 Jul 27;: Authors: Han W, Yu F, Wang R, Guan W, Zhi F Abstract Glioma is a highly malignant type of intracranial tumor with a poor prognosis resulting from traditional chemo-resistance with temozolomide (TMZ). Luteolin has been detected to exert limited anti-tumor effects on gliomas,...
Wed Jul 29, 2020 13:44
Related Articles The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1. Front Cell Dev Biol. 2020;8:498 Authors: Gažová I, Lefevre L, Bush SJ, Clohisey S, Arner E, de Hoon M, Severin J, van Duin L, Andersson R, Lengeling A, Hume DA, Summers KM Abstract The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has been widely studied to...
Wed Jul 29, 2020 13:44
Related Articles Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer. Cell Death Dis. 2020 Jul 27;11(7):582 Authors: Qi J, Zhou N, Li L, Mo S, Zhou Y, Deng Y, Chen T, Shan C, Chen Q, Lu B Abstract Ciclopirox (CPX) modulates multiple cellular pathways involved in the growth of a variety of tumor cell types. However, the effects of CPX on colorectal cancer (CRC) and the underlying mechanisms...
Wed Jul 29, 2020 13:44
Related Articles Lignan from Alnus japonica Inhibits Adipocyte Differentiation via Cell Cycle and FOXO1 Regulation. Molecules. 2020 Jul 23;25(15): Authors: Lee H, Jeong JH, Ryu JH Abstract In the present study, we isolated a lignan ((-)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol, DFS) from Alnus japonica and evaluated its antiobesity potential in vitro. We also determined its mechanism of action in a mouse pre-adipocyte 3T3-L1 cell line....
Wed Jul 29, 2020 13:44
Related Articles Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects. Angew Chem Int Ed Engl. 2019 01 14;58(3):769-774 Authors: Zhou W, Pan T, Cui H, Zhao Z, Chu PK, Yu XF Abstract Black phosphorus nanosheets (BPs) are demonstrated to be highly bioactive anti-cancer agents because of their inherent and selective chemotherapeutic effects. Fast intracellular biodegradation of BPs and acute elevation...
Wed Jul 29, 2020 13:44
Related Articles Ceasing Antiquated Conceptions: A Telling of the Early and Evolving History of Epilepsy. Eur Neurol. 2020 Jul 27;:1-4 Authors: Khalil N, Benbadis S, Robertson D Abstract The word epilepsy is derived from the Greek word epilambanein, meaning "to seize." This term came to embody the disease as early descriptions characterized seizures as events in which the faculties of the mind and body were "seized" from the individual. This...
Wed Jul 29, 2020 15:04
Related Articles Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion. Neurochem Res. 2020 Jul 27;: Authors: Durankuş F, Şenkal E, Sünnetçi E, Albayrak Y, Beyazyüz M, Atasoy Ö, Erbaş O Abstract Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties of ibuprofen...
Wed Jul 29, 2020 15:04
Related Articles Oxidative stress biomarkers in Fabry disease: is there a room for them? J Neurol. 2020 Jul 27;: Authors: Simoncini C, Torri S, Montano V, Chico L, Gruosso F, Tuttolomondo A, Pinto A, Simonetta I, Cianci V, Salviati A, Vicenzi V, Marchi G, Girelli D, Concolino D, Sestito S, Zedde M, Siciliano G, Mancuso M Abstract BACKGROUND: Fabry disease (FD) is an X-linked lysosomal storage disorder, caused by deficient activity of the alpha-galactosidase...
Wed Jul 29, 2020 15:04
Related Articles Epilepsy Care in the Time of COVID-19 Pandemic in Italy: Risk Factors for Seizure Worsening. Front Neurol. 2020;11:737 Authors: Assenza G, Lanzone J, Brigo F, Coppola A, Di Gennaro G, Di Lazzaro V, Ricci L, Romigi A, Tombini M, Mecarelli O Abstract Objective: In early 2020, Italy struggled with an unprecedented health emergency related to the COVID-19 pandemic. Medical care of chronic neurological diseases, such as epilepsy,...
Wed Jul 29, 2020 15:04
Related Articles The NMDA Receptor Antibody Paradox: A Possible Approach to Developing Immunotherapies Targeting the NMDA Receptor. Front Neurol. 2020;11:635 Authors: Young D Abstract N-methyl-D-aspartate receptors (NMDAR) play a key role in brain development and function, including contributing to the pathogenesis of many neurological disorders. Immunization against the GluN1 subunit of the NMDAR and the production of GluN1 antibodies is associated...
Wed Jul 29, 2020 15:04
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