Publication date: Available online 28 July 2020Source: Clinical NeurophysiologyAuthor(s): Femke Dijkstra, Mineke Viaene, Ilse De Volder, Erik Fransen, Patrick Cras, David Crosiers
Wed Jul 29, 2020 15:06
Key points The heavy‐to‐severe intensity exercise threshold (i.e. critical force) distinguishes between steady‐state and progressive metabolic and neuromuscular responses to exercise. High‐levels of skeletal muscle sensory feedback related to peripheral fatigue development are thought to restrict motor‐unit activation and limit exercise tolerance. Utilizing limb blood flow occlusion, we demonstrate that critical force reflects an oxygen‐delivery dependent balance between motor‐unit activation...
Tue Jul 28, 2020 16:08
Key points Presynaptic inhibition is modulated by supraspinal centers and primary afferents in order to filter sensory information, adjust spinal reflex excitability, and ensure smooth movements. After SCI, the supraspinal control of primary afferent depolarization (PAD) interneurons is disengaged, suggesting an increased role for sensory afferents. While increased H‐reflex excitability in spastic individuals indicates a possible decrease in presynaptic inhibition, it remains unclear whether...
Tue Jul 28, 2020 16:04
Key points 25OHD is a partial agonist of TRPV1 whereby 25OHD can weakly activate TRPV1 yet antagonize the stimulatory effects of the full TRPV1 agonists capsaicin and oleoyl dopamine. 25OHD binds to TRPV1 within the same vanilloid binding pocket as capsaicin. 25OHD inhibits the potentiating effects of PKC‐mediated TRPV1 activity. 25OHD reduces T‐cell activation and trigeminal neuron calcium signalling mediated by TRPV1 activity. These results provide evidence that TRPV1 is a novel receptor...
Tue Jul 28, 2020 15:33
Tue Jul 28, 2020 15:30
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