Τετάρτη 29 Ιουλίου 2020


[A step forward for thromboembolic disease treatment in patients with cancer].
Related Articles [A step forward for thromboembolic disease treatment in patients with cancer]. Bull Cancer. 2020 Jul 24;: Authors: Mignard X, Planquette B, Sanchez O, Wislez M PMID: 32718587 [PubMed - as supplied by publisher]
Association française pour l'étude du cancer
Wed Jul 29, 2020 15:43
"Round 4: 55-Word Stories of Medical Students' Clerkship Experiences".
Related Articles "Round 4: 55-Word Stories of Medical Students' Clerkship Experiences". Mil Med. 2020 Jul 28;: Authors: Aleman-Reyes DM, Alindogan A, Black JM, Horch MJ, Husson CM, Chang JG PMID: 32719882 [PubMed - as supplied by publisher]
Association of Military Surgeons of the United States
Wed Jul 29, 2020 14:20
Upregulation of miRNA-1228-3p alleviates TGF-β-induced fibrosis in renal tubular epithelial cells.
Related Articles Upregulation of miRNA-1228-3p alleviates TGF-β-induced fibrosis in renal tubular epithelial cells. Histol Histopathol. 2020 Jul 28;:18242 Authors: Shen H, He Q, Dong Y, Shao L, Liu Y, Gong J Abstract BACKGROUND: Chronic kidney disease (CKD) has become a major public health issue, which can lead to renal fibrosis regardless of the initial injury. It has been previously reported that miRNA-1228-3p was correlate with the progression...
Cellular and Molecular Biology
Wed Jul 29, 2020 15:47
Preclinical discovery and clinical development of encorafenib for the treatment of melanoma.
Related Articles Preclinical discovery and clinical development of encorafenib for the treatment of melanoma. Expert Opin Drug Discov. 2020 Jul 28;:1-8 Authors: Okten IN, Ismail S, Withycombe BM, Eroglu Z Abstract INTRODUCTION: Nearly 50% of patients with metastatic melanoma harbor a BRAFV600-mutation, which can be targeted with the use of BRAF and MEK inhibitors, either in the front-line or treatment-refractory setting. Encorafenib is the newest...
Expert Opinion on Drug Discovery
Wed Jul 29, 2020 18:35
Levofloxacin versus ceftriaxone for treatment of acute pyelonephritis in Iranian adults.
Related Articles Levofloxacin versus ceftriaxone for treatment of acute pyelonephritis in Iranian adults. Infect Disord Drug Targets. 2020 Jul 27;: Authors: Tehrani S, Elyasi F, Abolghasemi S Abstract INTRODUCTION: Acute pyelonephritis is among the most common bacterial infections. Options for initial treatment of pyelonephritis include an extended-spectrum cephalosporin or a fluoroquinolone. In this study, we aimed to compare the clinical outcomes...
Infectious disorders drug targets,http://goo.gl/XqkpND
Wed Jul 29, 2020 15:17
Drug susceptibility testing of Mycobacterium simiae: An emerging pathogen in Iran.
Related Articles Drug susceptibility testing of Mycobacterium simiae: An emerging pathogen in Iran. Infect Disord Drug Targets. 2020 Jul 26;: Authors: Nasiri MJ, Amini S, Nikpor Z, Arefzadeh S, Mousav SMJ, Goudarzi H Abstract INTRODUCTION: Mycobacterium simiaeis an emerging pathogen in Iran and little is known about drug susceptibility patterns of this pathogen. MATERIALS AND METHODS: Twenty-five clinical isolates of M. simiaefrom 80...
Infectious disorders drug targets,http://goo.gl/XqkpND
Wed Jul 29, 2020 15:17
In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases.
Related Articles In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases. Infect Disord Drug Targets. 2020 Jul 27;: Authors: Chowdhury T, Roymahapatra G, Mandal SM Abstract BACKGROUND: COVID-19 is a life threatening novel corona viral infection to our civilization and spreading rapidly. Terrific efforts are generous by the researchers...
Infectious disorders drug targets,http://goo.gl/XqkpND
Wed Jul 29, 2020 15:17
A Bibliometric Analysis of Global Research on Lophomonas sp. in Scopus (1933-2019).
Related Articles A Bibliometric Analysis of Global Research on Lophomonas sp. in Scopus (1933-2019). Infect Disord Drug Targets. 2020 Jul 27;: Authors: Keighobadi M, Nakhaei M, Sharifpour A, Khasseh AA, Safanavaei S, Tabaripour R, Aliyali M, Abedi S, Mehravaran H, Banimostafavi ES, Fakhar M Abstract BACKGROUND: This study was designed to analyze the global research on Lophomonas spp. using bibliometric techniques. METHODS: A bibliometric...
Infectious disorders drug targets,http://goo.gl/XqkpND
Wed Jul 29, 2020 15:17
Authors' response: Estimating the generation interval for COVID-19 based on symptom onset data.
Related Articles Authors' response: Estimating the generation interval for COVID-19 based on symptom onset data. Euro Surveill. 2020 Jul;25(29): Authors: Kremer C, Ganyani T, Chen D, Torneri A, Faes C, Wallinga J, Hens N PMID: 32720639 [PubMed - in process]
Institut de veille sanitaire (France) Communicable Disease Surveillance Centre (Great Britain) European Centre for Disease Prevention and Control,http://www.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss
Wed Jul 29, 2020 13:50
Authors' correction for Euro Surveill. 2020;25(18).
Related Articles Authors' correction for Euro Surveill. 2020;25(18). Euro Surveill. 2020 Jul;25(29): Authors: Eurosurveillance editorial team PMID: 32720638 [PubMed - in process]
Institut de veille sanitaire (France) Communicable Disease Surveillance Centre (Great Britain) European Centre for Disease Prevention and Control,http://www.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss
Wed Jul 29, 2020 13:50
Job vacancies at the European Centre for Disease Prevention and Control (ECDC).
Related Articles Job vacancies at the European Centre for Disease Prevention and Control (ECDC). Euro Surveill. 2020 Jul;25(29): Authors: Eurosurveillance editorial team PMID: 32720637 [PubMed - in process]
Institut de veille sanitaire (France) Communicable Disease Surveillance Centre (Great Britain) European Centre for Disease Prevention and Control,http://www.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss
Wed Jul 29, 2020 13:50
A large COVID-19 outbreak in a high school 10 days after schools' reopening, Israel, May 2020.
Related Articles A large COVID-19 outbreak in a high school 10 days after schools' reopening, Israel, May 2020. Euro Surveill. 2020 Jul;25(29): Authors: Stein-Zamir C, Abramson N, Shoob H, Libal E, Bitan M, Cardash T, Cayam R, Miskin I Abstract On 13 March 2020, Israel's government declared closure of all schools. Schools fully reopened on 17 May 2020. Ten days later, a major outbreak of coronavirus disease (COVID-19) occurred in a high school....
Institut de veille sanitaire (France) Communicable Disease Surveillance Centre (Great Britain) European Centre for Disease Prevention and Control,http://www.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss
Wed Jul 29, 2020 13:50
Letter to the editor: Generation interval for COVID-19 based on symptom onset data.
Related Articles Letter to the editor: Generation interval for COVID-19 based on symptom onset data. Euro Surveill. 2020 Jul;25(29): Authors: Bacallado S, Zhao Q, Ju N PMID: 32720635 [PubMed - in process]
Institut de veille sanitaire (France) Communicable Disease Surveillance Centre (Great Britain) European Centre for Disease Prevention and Control,http://www.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss
Wed Jul 29, 2020 13:50
Transmission of viral hepatitis through blood transfusion in Sweden, 1968 to 2012.
Related Articles Transmission of viral hepatitis through blood transfusion in Sweden, 1968 to 2012. Euro Surveill. 2020 Jul;25(29): Authors: Dahl V, Majeed A, Wikman A, Norda R, Edgren G Abstract IntroductionViral hepatitis remains a significant threat to transfusion safety, although largely mitigated by donor screening.AimOur objective was to estimate the past and present burden of transfusion transmission of all types of viral hepatitis (A...
Institut de veille sanitaire (France) Communicable Disease Surveillance Centre (Great Britain) European Centre for Disease Prevention and Control,http://www.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss
Wed Jul 29, 2020 13:50
Evolution of the speech-ready brain: The voice/jaw connection in the human motor cortex.
Related Articles Evolution of the speech-ready brain: The voice/jaw connection in the human motor cortex. J Comp Neurol. 2020 Jul 28;: Authors: Brown S, Yuan Y, Belyk M Abstract A prominent model of the origins of speech, known as the "frame/content" theory, posits that oscillatory lowering and raising of the jaw provided an evolutionary scaffold for the development of syllable structure in speech. Because such oscillations are non-vocal in...
Larynx
Wed Jul 29, 2020 16:38
Stage-specific expression analysis ofMMP-2 & MMP-9 in laryngeal carcinoma.
Related Articles Stage-specific expression analysis ofMMP-2 & MMP-9 in laryngeal carcinoma. J Cancer Res Ther. 2020 Apr-Jun;16(3):517-520 Authors: Bakshi J, Goyal AK, Singh V, Sannigrahi M, Khullar M Abstract Aim of the Study: Both matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) is involved in degradation of extracellular matrix and found to stimulate invasion and metastasis in cancer patients. However, studies...
Larynx
Wed Jul 29, 2020 16:38
Quality of life of head and neck cancer patients before and after cancer-directed treatment - A longitudinal study.
Related Articles Quality of life of head and neck cancer patients before and after cancer-directed treatment - A longitudinal study. J Cancer Res Ther. 2020 Apr-Jun;16(3):500-507 Authors: Bashir A, Kumar D, Dewan D, Sharma R Abstract Context: Head-and-neck cancer (HNC) is a major health problem worldwide and even disproportionately bigger in India. Their diagnosis and treatment create severe impact on the quality of life (QOL). We chose to study...
Larynx
Wed Jul 29, 2020 16:38
Evaluating different radiotherapy treatment plans, in terms of critical organ scoring index, conformity index, tumor control probability, and normal tissue complication probability calculations in early glottic larynx carcinoma.
Related Articles Evaluating different radiotherapy treatment plans, in terms of critical organ scoring index, conformity index, tumor control probability, and normal tissue complication probability calculations in early glottic larynx carcinoma. J Cancer Res Ther. 2020 Apr-Jun;16(3):485-493 Authors: Inal A, Duman E, Ozkan EE Abstract Purpose: In this study, it is aimed to compare three different radiotherapy treatment planning techniques in...
Larynx
Wed Jul 29, 2020 16:38
Is surgical resection without radioactive iodine treatment a safe alternative treatment for T1-2N1bM0 papillary thyroid carcinoma?
Related Articles Is surgical resection without radioactive iodine treatment a safe alternative treatment for T1-2N1bM0 papillary thyroid carcinoma? Auris Nasus Larynx. 2020 Jul 24;: Authors: Fujiwara T, Yoshizawa A, Mizuta M, Tamaki H Abstract OBJECTIVE: Postoperative radioactive iodine (RAI) adjuvant therapy improves the prognosis in patients with advanced papillary thyroid carcinoma (PTC), although the role of RAI adjuvant therapy remains...
Larynx
Wed Jul 29, 2020 16:38
Minimal temperature, mean wind speed, and mean relative humidity are associated with spontaneous epistaxis in Seoul, Korea.
Related Articles Minimal temperature, mean wind speed, and mean relative humidity are associated with spontaneous epistaxis in Seoul, Korea. Auris Nasus Larynx. 2020 Jul 25;: Authors: Min SJ, Kang H, Kim KS, Min HJ Abstract OBJECTIVE: Epistaxis is a commonly encountered condition; however, factors that have been associated with epistaxis are controversial. Although several previous studies have evaluated the relationship between meteorological...
Larynx
Wed Jul 29, 2020 16:38
A low-cost portable simulator of a domestic cat larynx for teaching endotracheal intubation.
Related Articles A low-cost portable simulator of a domestic cat larynx for teaching endotracheal intubation. Vet Anaesth Analg. 2020 Jun 05;: Authors: Clausse M, Nejamkin P, Bulant CA, Genaro A, Landivar F, Del Sole MJ, Clausse A Abstract OBJECTIVE: To design and construct an affordable simulator of the cat larynx for training intubation maneuvers and to share the designs for its fabrication. STUDY DESIGN: Research and development...
Larynx
Wed Jul 29, 2020 16:38
Cohort Analysis of Epithelial Cancer Mortality Male-to-Female Sex Ratios in the European Union, USA, and Japan.
Related Articles Cohort Analysis of Epithelial Cancer Mortality Male-to-Female Sex Ratios in the European Union, USA, and Japan. Int J Environ Res Public Health. 2020 Jul 23;17(15): Authors: Carioli G, Bertuccio P, Levi F, Boffetta P, Negri E, Vecchia C, Malvezzi M Abstract OBJECTIVE: To illustrate trends in sex ratios in epithelial cancer mortality in the EU, USA, and Japan, with a focus on age-specific and cohort patterns. METHODS:...
Larynx
Wed Jul 29, 2020 16:38
Rescue oxygenation success by cannula or scalpel-bougie emergency front-of-neck access in an anaesthetised porcine model.
Related Articles Rescue oxygenation success by cannula or scalpel-bougie emergency front-of-neck access in an anaesthetised porcine model. PLoS One. 2020;15(5):e0232510 Authors: Umek N, Hodzovic I, Damjanovska M, Cvetko E, Zel J, Seliskar A, Pintaric TS Abstract In the obese, the evidence for the choice of the optimal emergency front-of-neck access technique is very limited and conflicting. We compared cannula and scalpel-bougie emergency...
Larynx
Wed Jul 29, 2020 16:38
Measurement of blood lactate as a function of vocal loading and neuromuscular electrical stimulation: Proof of concept.
Related Articles Measurement of blood lactate as a function of vocal loading and neuromuscular electrical stimulation: Proof of concept. J Commun Disord. 2019 Jul - Aug;80:92-100 Authors: Gorham-Rowan M, Morris R, Waggener G Abstract The goal of the current investigation was to establish proof of concept regarding measurement of blood lactate levels as an indicator of laryngeal muscle activity and fatigue, as well as to examine the relationship...
Larynx
Wed Jul 29, 2020 16:38
Mesoscopic Mapping of Stimulus-Selective Response Plasticity in the Visual Pathways Modulated by the Cholinergic System.
Related Articles Mesoscopic Mapping of Stimulus-Selective Response Plasticity in the Visual Pathways Modulated by the Cholinergic System. Front Neural Circuits. 2020;14:38 Authors: Laliberté G, Othman R, Vaucher E Abstract The cholinergic potentiation of visual conditioning enhances visual acuity and discrimination of the trained stimulus. To determine if this also induces long-term plastic changes on cortical maps and connectivity in the visual...
Neural-circuits,http://goo.gl/r3fv60
Wed Jul 29, 2020 13:39
Current and Future Research Into the Mechanism of Action of Regorafenib.
Related Articles Current and Future Research Into the Mechanism of Action of Regorafenib. Clin Adv Hematol Oncol. 2019 Aug;17 Suppl 12(8):14-16 Authors: Yoshino T PMID: 32720934 [PubMed - as supplied by publisher]
Oncology
Wed Jul 29, 2020 14:28
The first study in pediatric: Population pharmacokinetics of sirolimus and its application in Chinese children with immune cytopenia.
Related Articles The first study in pediatric: Population pharmacokinetics of sirolimus and its application in Chinese children with immune cytopenia. Int J Immunopathol Pharmacol. 2020 Jan-Dec;34:2058738420934936 Authors: Cheng X, Zhao Y, Gu H, Zhao L, Zang Y, Wang X, Wu R Abstract The narrow therapeutic index and large inter-individual variability in sirolimus pharmacokinetics (PK) make therapeutic drug monitoring (TDM) necessary. Factors...
Oncology
Wed Jul 29, 2020 14:28
Rare cancers in Japan: definition, clinical features and future perspectives.
Related Articles Rare cancers in Japan: definition, clinical features and future perspectives. Jpn J Clin Oncol. 2020 Jul 28;: Authors: Kawai A, Higashi T, Shibata T, Yoshida A, Katoh Y, Fujiwara Y, Nishida T Abstract This review introduces the definition, epidemiology and therapeutic challenges of rare cancers and describes the establishment of the Rare Cancer Center at the National Cancer Center, Japan. Rare cancers are defined as malignant...
Oncology
Wed Jul 29, 2020 14:28
rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.
Related Articles rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461. Front Cell Dev Biol. 2020;8:568 Authors: Son J, Hannan KM, Poortinga G, Hein N, Cameron DP, Ganley ARD, Sheppard KE, Pearson RB, Hannan RD, Sanij E Abstract Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent...
Oncology
Wed Jul 29, 2020 14:28
In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their Lifecycles.
Related Articles In-Depth Bioinformatic Analyses of Nidovirales Including Human SARS-CoV-2, SARS-CoV, MERS-CoV Viruses Suggest Important Roles of Non-canonical Nucleic Acid Structures in Their Lifecycles. Front Microbiol. 2020;11:1583 Authors: Bartas M, Brázda V, Bohálová N, Cantara A, Volná A, Stachurová T, Malachová K, Jagelská EB, Porubiaková O, Červeň J, Pečinka P Abstract Non-canonical nucleic acid structures play important roles in the...
Oncology
Wed Jul 29, 2020 14:28
Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial.
Related Articles Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial. Cell Res. 2020 Jul 27;: Authors: Jiang YZ, Liu Y, Xiao Y, Hu X, Jiang L, Zuo WJ, Ma D, Ding J, Zhu X, Zou J, Verschraegen C, Stover DG, Kaklamani V, Wang ZH, Shao ZM Abstract Triple-negative breast cancer (TNBC) is a highly heterogeneous disease, and molecular subtyping may result in improved...
Oncology
Wed Jul 29, 2020 14:28
Bioactive DNA from extracellular vesicles and particles.
Related Articles Bioactive DNA from extracellular vesicles and particles. Cell Death Dis. 2020 Jul 27;11(7):584 Authors: Malkin EZ, Bratman SV Abstract Extracellular vesicles (EVs) and particles (EPs) have recently emerged as active carriers of molecular biomarkers and mediators of intercellular communication. While most investigations have focused exclusively on the protein, lipid and RNA constituents of these extracellular entities, EV/EP...
Oncology
Wed Jul 29, 2020 14:28
Stereotactic Radiosurgery and Stereotactic Body Radiotherapy in the Management of Oligometastatic Disease.
Related Articles Stereotactic Radiosurgery and Stereotactic Body Radiotherapy in the Management of Oligometastatic Disease. Clin Oncol (R Coll Radiol). 2020 Jul 24;: Authors: Chen H, Louie AV, Higginson DS, Palma DA, Colaco R, Sahgal A Abstract Stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) represent non-invasive, efficacious and safe radiation treatments for the ablation of intracranial and extracranial metastases....
Oncology
Wed Jul 29, 2020 14:28
Radioprotective effects of induced astronaut torpor and advanced propulsion systems during deep space travel.
Related Articles Radioprotective effects of induced astronaut torpor and advanced propulsion systems during deep space travel. Life Sci Space Res (Amst). 2020 Aug;26:105-113 Authors: Squire T, Ryan A, Bernard S Abstract BACKGROUND: Human metabolic suppression is not a new concept, with 1950s scientific literature and movies demonstrating its potential use for deep space travel (Hock, 1960). An artificially induced state of metabolic suppression...
Oncology
Wed Jul 29, 2020 14:28
Risk Stratification Is Helpful in Designing Follow-Up Strategy and Future Studies on Adjuvant Therapies: Response to the External Validation on the Chinese Alliance for Research in Thymomas Predictive Model of Recurrence.
Related Articles Risk Stratification Is Helpful in Designing Follow-Up Strategy and Future Studies on Adjuvant Therapies: Response to the External Validation on the Chinese Alliance for Research in Thymomas Predictive Model of Recurrence. J Thorac Oncol. 2020 Aug;15(8):e139-e141 Authors: Gu Z, Liu Y, Qiu B, Liu H, Fang W PMID: 32718540 [PubMed - in process]
Oncology
Wed Jul 29, 2020 14:28
13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts.
Related Articles 13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts. Mar Drugs. 2020 Jul 23;18(8): Authors: Liu YC, Peng BR, Hsu KC, El-Shazly M, Shih SP, Lin TE, Kuo FW, Chou YC, Lin HY, Lu MC Abstract 13-Acetoxysarcocrassolide (13-AC), a marine cytotoxic product isolated from the alcyonacean coral Lobophytum...
Oncology
Wed Jul 29, 2020 14:28
Molecular Targets, Pathways, and Therapeutic Implications for Hepatocellular Carcinoma.
Related Articles Molecular Targets, Pathways, and Therapeutic Implications for Hepatocellular Carcinoma. Int J Mol Sci. 2020 Jul 23;21(15): Authors: Gong J, Chuang J, Cho M, Toomey K, Hendifar A, Li D Abstract Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer mortality worldwide. While significant advances have been made for the treatment of advanced hepatocellular carcinoma in the past few years, the prognosis remains...
Oncology
Wed Jul 29, 2020 14:28
Application of the UHPLC-DIA-HRMS Method for Determination of Cheese Peptides.
Related Articles Application of the UHPLC-DIA-HRMS Method for Determination of Cheese Peptides. Foods. 2020 Jul 23;9(8): Authors: Arju G, Taivosalo A, Pismennoi D, Lints T, Vilu R, Daneberga Z, Vorslova S, Renkonen R, Joenvaara S Abstract Until now, cheese peptidomics approaches have been criticised for their lower throughput. Namely, analytical gradients that are most commonly used for mass spectrometric detection are usually over 60 or even...
Oncology
Wed Jul 29, 2020 14:28

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